by MITx: 7.28.1x Molecular Biology
Leonard Zon and colleagues describe how stem cells induce remodeling of the perivascular niche.
ARLINGTON, VA – November 20, 2014 – On Tuesday, November 18, winners of the 2014 Life Science Industry Awards® were formally announced at the Grand Hyatt Washington in Washington, DC. The Life Science Industry Awards recognizes those life science suppliers that are best-in-class in 28 product and service categories.
The awards were presented by BioInformatics LLC, the premier market research and advisory firm serving the life science industry. The event was attended by industry executives and product and marketing professionals from 41 life science companies
Using industry best-practices market research methodologies, almost 6,000 scientists were surveyed to reveal preferred suppliers in 28 product, communications, and support categories. These scientists were drawn from BioInformatics LLC’s online panel of scientists, The Science Advisory Board®. From the data collected, BioInformatics LLC analysts calculated an overall score for each nominated company based on the number of nominations received, as well as key measurements of customer satisfaction and loyalty.
“The vision and foresight of the companies we honored last night have made possible many of the scientific advances of the past decade,” said Jennifer Cotteleer, CEO of BioInformatics LLC. “Life science tools companies are the foundation upon which biological research and drug discovery rest and we are proud to support them in understanding the needs of their scientific customers.”
The Winners of the prestigious 2014 Life Science Industry Awards® are:
Best Use of Digital Media
Best High Throughput Screening & Analysis Systems
Becton, Dickinson & Co.
Best Cell Analysis Instruments (Flow Cytometer-Based)
Best Technical Support
Best Workflow Solutions – Cell-Based Research
Most Memorable Advertising
Best Protein Expression & Analysis Products
Best Workflow Solutions – Genomics
Best Cell Biology Instruments (Microscope-Based)
Breakthrough Product – Neuroscience Research
Cell Signaling Technology
Most Useful Website
“Greenest” Life Science Company
Best General Lab Equipment
GE Healthcare Life Sciences
Best Instrumentation for Protein Analysis & Purification
Best Protein Purification & Separation Products
Best High Throughput Sequencing Platform
Life Technologies (Thermo Fisher Scientific)
Best Cell Biology Products
Best Cell Culture Media & Reagents
Best Genomics Analysis Kits & Reagents
Best Instrumentation for Genomic Analysis
New England Biolabs
Best Molecular Biology Products
Best Nucleic Acid Purification & Separation Products
Most Helpful Sales Force
Company to Watch in 2015
Best Customer Service
Thermo Fisher Scientific
Best Workflow Solutions – Proteomics
2014 Market Leadership Award
This year’s event was supported by the generous sponsorship of the Association of Commercial Professionals-Life Science, the Biotechnology Industry Organization, BroadOak Capital Partners, and UP, There Everywhere.
ABOUT BIOINFORMATICS LLC
Now celebrating 20 years in business, BioInformatics LLC and its SDi division form the premier research and advisory firm serving the life science industry. By leveraging our expert network of more than 72,000 life scientists, the company has supported more than 500 companies in creating insights that lead to better business decisions. Offerings include assessing the size and attractiveness of scientific markets, optimizing product configurations and pricing, validating corporate acquisitions, measuring customer loyalty, and evaluating brand strength and positioning.
The Nobel Assembly at Karolinska Institutet has today decided to award
The 2014 Nobel Prize in Physiology or Medicine
with one half to
and the other half jointly to
May-Britt Moser and Edvard I. Moser
for their discoveries of cells that constitute a positioning
system in the brain
How do we know where we are? How can we find the way from one place to another? And how can we store this information in such a way that we can immediately find the way the next time we trace the same path? This year´s Nobel Laureates have discovered a positioning system, an “inner GPS” in the brain that makes it possible to orient ourselves in space, demonstrating a cellular basis for higher cognitive function.
In 1971, John O´Keefe discovered the first component of this positioning system. He found that a type of nerve cell in an area of the brain called the hippocampus that was always activated when a rat was at a certain place in a room. Other nerve cells were activated when the rat was at other places. O´Keefe concluded that these “place cells” formed a map of the room.
More than three decades later, in 2005, May-Britt and Edvard Moser discovered another key component of the brain’s positioning system. They identified another type of nerve cell, which they called “grid cells”, that generate a coordinate system and allow for precise positioning and pathfinding. Their subsequent research showed how place and grid cells make it possible to determine position and to navigate.
The discoveries of John O´Keefe, May-Britt Moser and Edvard Moser have solved a problem that has occupied philosophers and scientists for centuries – how does the brain create a map of the space surrounding us and how can we navigate our way through a complex environment?
How do we experience our environment?
The sense of place and the ability to navigate are fundamental to our existence. The sense of place gives a perception of position in the environment. During navigation, it is interlinked with a sense of distance that is based on motion and knowledge of previous positions.
Questions about place and navigation have engaged philosophers and scientists for a long time. More than 200 years ago, the German philosopher Immanuel Kant argued that some mental abilities exist as a priori knowledge, independent of experience. He considered the concept of space as an inbuilt principle of the mind, one through which the world is and must be perceived. With the advent of behavioural psychology in the mid-20th century, these questions could be addressed experimentally. When Edward Tolman examined rats moving through labyrinths, he found that they could learn how to navigate, and proposed that a “cognitive map” formed in the brain allowed them to find their way. But questions still lingered – how would such a map be represented in the brain?
John O´Keefe and the place in space
John O´Keefe was fascinated by the problem of how the brain controls behaviour and decided, in the late 1960s, to attack this question with neurophysiological methods. When recording signals from individual nerve cells in a part of the brain called the hippocampus, in rats moving freely in a room, O’Keefe discovered that certain nerve cells were activated when the animal assumed a particular place in the environment (Figure 1). He could demonstrate that these “place cells” were not merely registering visual input, but were building up an inner map of the environment. O’Keefe concluded that the hippocampus generates numerous maps, represented by the collective activity of place cells that are activated in different environments. Therefore, the memory of an environment can be stored as a specific combination of place cell activities in the hippocampus.
May-Britt and Edvard Moser find the coordinates
May-Britt and Edvard Moser were mapping the connections to the hippocampus in rats moving in a room when they discovered an astonishing pattern of activity in a nearby part of the brain called the entorhinal cortex. Here, certain cells were activated when the rat passed multiple locations arranged in a hexagonal grid (Figure 2). Each of these cells was activated in a unique spatial pattern and collectively these “grid cells” constitute a coordinate system that allows for spatial navigation. Together with other cells of the entorhinal cortex that recognize the direction of the head and the border of the room, they form circuits with the place cells in the hippocampus. This circuitry constitutes a comprehensive positioning system, an inner GPS, in the brain (Figure 3). Continue reading
The Ebola virus and it’s close relative the Marburg virus are members of the Filoviridae family. These viruses are the causative agents of severe hemorrhagic fever, a disease with a fatality rate of up to 90% . The Ebola virus infects mainly the capillary endothelium and several types of immune cells. The symptoms of Ebola infection include maculopapular rash, petechiae, purpura, ecchymoses, dehydration and hematomas .
Since Ebola was first described in 1976, there have been several epidemics of this disease. Hundreds of people have died because of Ebola infections, mainly in Zaire, Sudan, Congo and Uganda . In addition, several fatalities have occurred because of accidents in laboratories working with the virus . Currently, a number of scientists claim that terrorists may use Ebola as a biological weapon [14, 16].
In the 3D model presented in this study, Ebola-encoded structures are shown in maroon, and structures from human cells are shown in grey. The Ebola model is based on X-ray analysis, NMR spectroscopy, and general virology data published in the last two decades. Some protein structures were predicted using computational biology techniques, such as molecular modeling.
As the largest collaborative of its kind, the Harvard Stem Cell Institute is a unique scientific enterprise — a community of scientists and clinical experts in stem cell science seeking to bring new treatments to the clinic and new life to patients with a wide range of chronic illnesses.
To pursue the promise of stem cell and regenerative biology, in 2004, Harvard created a novel academic home for researchers and students, and a network of stem cell scientists extending from the University to its affiliated hospitals and the biomedical industry. Leveraging this unique environment, Harvard’s program has helped to change the paradigm for biomedical research and education by emphasizing cooperative teams and student participation in cutting-edge science.
The Harvard community consists of the largest concentration of biomedical researchers in the world, which allows us to advance stem cell biology and translational medicine in a way no other single entity can. Stem cell biologists across all the departments, schools, institutes, and affiliated hospitals of Harvard are able to collaborate on a daily basis with scientist-physicians, chemists, bioengineers, experts in business, law, and ethics, in order to develop tomorrow’s treatments and cures today.
The brain is the most complex biological structure in the known universe. It is a topic rich with exciting new discoveries, continuing profound unknowns, and critical implications for individuals, families, and societies.
The site is a public information initiative of The Kavli Foundation, the Gatsby Charitable Foundation, and the Society for Neuroscience, all leading global nonprofit organizations working to advance brain research. Leading neuroscientists from around the world form theBrainFacts.org editorial board.
Why create a website?
The study of brain structure and function is called neuroscience. BrainFacts.org seeks to share what neuroscientists know, explore what they don’t yet know fully, and discuss how today’s research advances understanding. The site’s content, which is reviewed by scientists for accuracy, seeks to:
BrainFacts.org also shares the excitement of scientific discovery, and educates about the scientific process. Like other scientific disciplines, the path to understanding the brain is long and complex. It can twist and turn unexpectedly, revealing both new knowledge and, sometimes, surprising results. It demonstrates how science makes progress through continuous inquiry, testing, debate, and refinement.
Accuracy, accessibility, transparency
The information on BrainFacts.org is regularly fact-checked and updated. All site content is reviewed for accuracy, either by Society for Neuroscience members or by trusted content partners approved by the BrainFacts.org editorial board.
BrainFacts.org provides information about the field’s understanding of causes, symptoms, and outcomes of brain disorders. It is not intended to give specific medical or other advice to patients. Visitors interested in medical advice should consult with a physician.
Founded in 1912, the Federation of American Societies for Experimental Biology (FASEB) was originally created by three independent scientific organizations to provide a forum in which to hold educational meetings, develop publications, and disseminate biological research results. What started as a small group of dedicated scientists has grown to be the nation’s largest coalition of biomedical researchers, representing 27 scientific societies and over 120,000 researchers from around the world. FASEB is now recognized as the policy voice of biological and biomedical researchers.
- Celebrated 100 years in 2012!
- 27 scientific societies / over 120,000 researchers worldwide
- Provides society management services
- Manages many scientific meetings, conferences, and exhibit halls each year
- Publishes The FASEB Journal
- Provides career resources through job/resume postings, networking, and educational seminars
- Located in Bethesda, MD – 1 mile from NIH and 8.5 miles from Washington D.C.
- Be part of an organization whose primary focus is to advocate and support the advancement of biological and biomedical sciences
- Better utilize financial resources and human capital
- Gain greater access to networking, career advancement, and cutting edge research
- Put science first
– See more at: http://www.faseb.org/About-FASEB/Who-We-Are.aspx#sthash.kbHNarhX.dpuf